O-056 Dysmorphic uterus: lateral angle might associate with euploid blastocyst implantation

Abstract Study question Are there a morphological features measured in coronal plane obtained by tridimensional transvaginal sonography (3D-TVS), associated with euploid blastocyst implantation? Summary answer Mean laeral angle (mLA) below 143 degrees was lower clinical pregnancy rate among 47 transfers. What is known already The ESHRE/ESGE 2013 consensus on uterine malformation clustered Class U1 (namely Dysmorphic uterus): T-shaped uterus (class U1a), infantilis (Class U1b) and U1c including other minor abnormalities. Diagnostic criteria are still under major debate, however few studies report an association between dysmorphic impaired fertility outcomes. In the literature, no evidence has been published selected population of Moreover, sonographic predictors successful transfer patients undergoing ART not available. design, size, duration Cohort study involving 122 infertile couples ICSI NGS-based PGT-A trophectoderm biopsies July-2022 December-2023. A 3D-TVS acquired luteal phase before starting ovarian stimulation. primary outcome to assess whether associate rate, defined as ultrasonographic gestational sac fetal heartbeat per transfer. To date, underwent vitrified-warmed single Participants/materials, setting, methods Uterine morphology assessed plane. Following measurements, we registered: (1) distance two internal tubal ostia, (2) width cavity at corpus-isthmic level, (3) lateral cavity, (4) indentation. optimal cut-off values mLA evaluated ROC curve; p < 0.05 considered statistically significant. SPSS version 25.0 used for statistics. Main results role chance Median age 38 (IR:26-43). main cause infertility tubal/ovulatory 22 cases (46%), severe male factor 18 (39%) idiopathic (39%). Thirteen women (28%) experienced previous miscarriage, half them were submitted revision. ranged from 126 180 (median:156 degrees), whereas mean indentation 0 7.2 mm (median: 3.0 mm). categorized 2 groups cutoff value calculated based curve analysis. case (mean right left angle) (sensitivity 90%, specificity 54%; AUC=0.67). levels higher than this threshold 37 (80%). Relative risk have 0.35 (95%CI 0.15-0.83) uterus. Two (25%) got pregnant group compared (72%) normal (p:0.026). After adjusting quality day transfer, remained significant (RR 7.38, 95%CI 1.09-50.18 = 0.04, Post hoc power: 65.3%). Limitations, reasons caution Preliminary results. larger sample required confirm these data. Wider implications findings strength definition impact IVF cycles PGT-A. If confirmed multicenter datasets, data may select who could benefit hysteroscopic metroplasty. Trial registration number applicable